Magali Richard

Magali Richard

I am a CNRS researcher in bioinformatics, with a background in molecular biology, genetics, and computational biology. My research focuses on tumor heterogeneity, method development, and cancer biology, and I also promote collaborative science by organizing data challenges.

On the Promises and Limits of Multi-omics Integration for Deconvolution: The HADACA3 Benchmark

This study introduces HADACA3, a large-scale community benchmark evaluating whether integrating DNA methylation and RNA data improves cell deconvolution accuracy across diverse biological settings. The results show that DNA methylation alone provides the most robust overall performance, while multi-omics integration can outperform single-modality approaches in specific datasets and configurations, highlighting a trade-off between robustness and peak accuracy.

Recommended citation: Hugo Barbot, Elise Amblard, Nicolas Homberg, Lucie Lamothe et al, On the Promises and Limits of Multi-omics Integration for Deconvolution: The HADACA3 Benchmark 2026.
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