Magali Richard

Magali Richard

I am a CNRS researcher in bioinformatics, with a background in molecular biology, genetics, and computational biology. My research focuses on tumor heterogeneity, method development, and cancer biology, and I also promote collaborative science by organizing data challenges.

DNA methylation and immune infiltration mediate the impact of tobacco exposure on pancreatic adenocarcinoma outcome: a high-dimensional mediation analysis

In this work, we developed HDMAX2-surv, a novel framework for high-dimensional mediation analysis specifically adapted to censored survival data. Our approach integrates computational immune deconvolution with causal discovery and serial mediation analysis, addressing a critical methodological gap in understanding how molecular intermediates shape clinical outcomes.

Recommended citation: DNA methylation and immune infiltration mediate the impact of tobacco exposure on pancreatic adenocarcinoma outcome: a high-dimensional mediation analysis. Florence Pittion, Elise Amblard, Emilie Devijver, Adeline Samson, Nelle Varoquaux, Magali Richard. bioRxiv 2025.09.09.675033; doi: https://doi.org/10.1101/2025.09.09.675033
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